up and at 'em
Get going, get busy, as in Up and at 'em—there's a lot of work to be done. This colloquial idiom, often uttered as a command, uses at 'em (for “at them”) in the general sense of tackling a project, and not in reference to specific persons.
Words nearby up and at 'em
up,
up a creek,
up a tree,
up against,
up and about,
up and at 'em,
up close and personal,
up for grabs,
up front,
up in arms,
up in the air