Spanish Main
noun
(formerly) the mainland of America adjacent to the Caribbean Sea, especially the area between the mouth of the Orinoco River and the Isthmus of Panama.
the Caribbean Sea: the route of the Spanish treasure galleons and a former haunt of pirates.
British Dictionary definitions for spanish main
Spanish Main
noun
the mainland of Spanish America, esp the N coast of South America from the Isthmus of Panama to the mouth of the Orinoco River, Venezuela
the Caribbean Sea, the S part of which in colonial times was the route of Spanish treasure galleons and the haunt of pirates