go against the grain
To go contrary to someone's natural disposition: “Having to get up this early in the morning really goes against my grain.” This refers to the fact that someone who rubs his hand against the grain on a piece of lumber will get splinters.
Words nearby go against the grain
go a long way,
go a long way toward,
go about,
go after,
go against,
go against the grain,
go ahead,
go all out,
go all the way,
go along,
go and